Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound

mBio (Apr 2021)

Affiliations

Britta E. Rued: ORCiD; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
Brett C. Covington: Department of Chemistry, Princeton University, Princeton, New Jersey, USA
Leah B. Bushin: Department of Chemistry, Princeton University, Princeton, New Jersey, USA
Gabriella Szewczyk: Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
Irina Laczkovich: Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
Mohammad R. Seyedsayamdost: Department of Chemistry, Princeton University, Princeton, New Jersey, USA
Michael J. Federle: ORCiD; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois, USA

Abstract

Bacteria interact and compete with a large community of organisms in their natural environment. Streptococcus mutansS. mutans