Organocatalytic atroposelective heterocycloaddition to access axially chiral 2-arylquinolines

Abstract

2-Arylquinoline derivatives are key components of many enantioselective catalysts, but existing synthetic routes are few in number. Here atroposelective aminocatalytic aza-Michael addition of amino-benzaldehydes to iminium intermediates yields single-enantiomer 2- arylquinoline derivatives with high selectivity