Nature Communications (Aug 2020)
Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells
- Na Zhu,
- Wenling Wang,
- Zhidong Liu,
- Chaoyang Liang,
- Wen Wang,
- Fei Ye,
- Baoying Huang,
- Li Zhao,
- Huijuan Wang,
- Weimin Zhou,
- Yao Deng,
- Longfei Mao,
- Chongyu Su,
- Guangliang Qiang,
- Taijiao Jiang,
- Jincun Zhao,
- Guizhen Wu,
- Jingdong Song,
- Wenjie Tan
Affiliations
- Na Zhu
- NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Wenling Wang
- NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Zhidong Liu
- Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University (Beijing Tuberculosis and Thoracic Tumor Research Institute)
- Chaoyang Liang
- Department of Thoracic Surgery, China–Japan Friendship Hospital
- Wen Wang
- NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Fei Ye
- NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Baoying Huang
- NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Li Zhao
- NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Huijuan Wang
- NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Weimin Zhou
- NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Yao Deng
- NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Longfei Mao
- Suzhou Institute of Systems Medicine
- Chongyu Su
- Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University (Beijing Tuberculosis and Thoracic Tumor Research Institute)
- Guangliang Qiang
- Department of Thoracic Surgery, China–Japan Friendship Hospital
- Taijiao Jiang
- Suzhou Institute of Systems Medicine
- Jincun Zhao
- State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University
- Guizhen Wu
- NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Jingdong Song
- NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Wenjie Tan
- NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- DOI
- https://doi.org/10.1038/s41467-020-17796-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 8
Abstract
Here, the authors characterize replication of SARS-CoV-2 in human airway epithelial (HAE) cultures and show that it can infect ciliated and secretory cells, affects transepithelial electrical resistance and causes plaque-like cytopathic effects associated with apoptosis.
