Nature Communications (May 2019)
Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis
Abstract
Dopamine dysregulation is centrally linked to major psychosis. Here, the authors characterise the hypomethylation of an enhancer within the insulin-like growth factor 2 gene in neurons of patients with major psychosis and provide evidence that this enhancer targets the tyrosine hydroxylase gene, responsible for dopamine synthesis.