Nature Communications (May 2019)

Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis

  • Shraddha Pai,
  • Peipei Li,
  • Bryan Killinger,
  • Lee Marshall,
  • Peixin Jia,
  • Ji Liao,
  • Arturas Petronis,
  • Piroska E. Szabó,
  • Viviane Labrie

DOI
https://doi.org/10.1038/s41467-019-09786-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Dopamine dysregulation is centrally linked to major psychosis. Here, the authors characterise the hypomethylation of an enhancer within the insulin-like growth factor 2 gene in neurons of patients with major psychosis and provide evidence that this enhancer targets the tyrosine hydroxylase gene, responsible for dopamine synthesis.