Nature Communications (Sep 2022)
The TFEB-TGIF1 axis regulates EMT in mouse epicardial cells
- Elena Astanina,
- Gabriella Doronzo,
- Davide Corà,
- Francesco Neri,
- Salvatore Oliviero,
- Tullio Genova,
- Federico Mussano,
- Emanuele Middonti,
- Edoardo Vallariello,
- Chiara Cencioni,
- Donatella Valdembri,
- Guido Serini,
- Federica Limana,
- Eleonora Foglio,
- Andrea Ballabio,
- Federico Bussolino
Affiliations
- Elena Astanina
- Department of Oncology, University of Torino
- Gabriella Doronzo
- Department of Oncology, University of Torino
- Davide Corà
- Department of Translational Medicine, Università degli Studi del Piemonte Orientale
- Francesco Neri
- Department of Life Sciences and Systems Biology, University of Torino
- Salvatore Oliviero
- Department of Life Sciences and Systems Biology, University of Torino
- Tullio Genova
- Department of Life Sciences and Systems Biology, University of Torino
- Federico Mussano
- CIR Dental School, Department of Surgical Sciences, University of Torino
- Emanuele Middonti
- Department of Oncology, University of Torino
- Edoardo Vallariello
- Department of Oncology, University of Torino
- Chiara Cencioni
- Institute for Systems Analysis and Computer Science “A. Ruberti”, National Research Council (IASI-CNR)
- Donatella Valdembri
- Department of Oncology, University of Torino
- Guido Serini
- Department of Oncology, University of Torino
- Federica Limana
- San Raffaele Open University
- Eleonora Foglio
- Technoscience, Parco Scientifico e Tecnologico Pontino
- Andrea Ballabio
- Telethon Institute of Genetics and Medicine (TIGEM)
- Federico Bussolino
- Department of Oncology, University of Torino
- DOI
- https://doi.org/10.1038/s41467-022-32855-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
Epithelial-mesenchymal transition (EMT) is a complex process involved in organogenesis. Here, the authors show that the transcription factor EB (TFEB) regulates EMT in epicardium during heart development by tuning sensitivity to TGFβ signaling.
