Comprehensive analysis of normal adjacent to tumor transcriptomes

Dvir Aran; Roman Camarda; Justin Odegaard; Hyojung Paik; Boris Oskotsky; Gregor Krings; Andrei Goga; Marina Sirota; Atul J. Butte

doi:10.1038/s41467-017-01027-z

Nature Communications (Oct 2017)

Comprehensive analysis of normal adjacent to tumor transcriptomes

Dvir Aran,
Roman Camarda,
Justin Odegaard,
Hyojung Paik,
Boris Oskotsky,
Gregor Krings,
Andrei Goga,
Marina Sirota,
Atul J. Butte

Affiliations

Dvir Aran: Institute for Computational Health Sciences, University of California
Roman Camarda: Department of Cell and Tissue Biology, University of California
Justin Odegaard: Department of Pathology, Stanford University Medical Center
Hyojung Paik: Institute for Computational Health Sciences, University of California
Boris Oskotsky: Institute for Computational Health Sciences, University of California
Gregor Krings: Department of Pathology, University of California
Andrei Goga: Department of Cell and Tissue Biology, University of California
Marina Sirota: Institute for Computational Health Sciences, University of California
Atul J. Butte: Institute for Computational Health Sciences, University of California

DOI: https://doi.org/10.1038/s41467-017-01027-z
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

Normal tissue adjacent to the tumour (NAT) is often used as a control in cancer studies. Here, the authors analyse across cancer types the transcriptomes of healthy, NAT, and tumour tissues, and find that NAT presents a unique state, potentially due to inflammatory response of the NAT to the tumour tissue.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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