Intestinal microflora dysbiosis and resistome in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)

Abstract

The aim of the present study is to explore the bacterial diversity within the gut microbiome of chronic inflammatory demyelinating polyneuropathy patient. A stool sample was collected and analyzed to study the gut microbiota through bacterial 16S rRNA gene sequencing. The gut microbiota of chronic inflammatory demyelinating polyneuropathy patient exhibited a dominance of Firmicutes and Bacteroides phyla, with 58.19% and 33.31%, respectively. The data showed a notable abundance of Lachnospiraceae bacterium and Bacteroides sp species, 17.79% and 16.56%, respectively within the gut microbiota chronic inflammatory demyelinating polyneuropathy patient. Lachnospiraceae, a member of the Firmicutes phylum, plays a pivotal role in the production of short-chain fatty acids. At high concentration, short-chain fatty acids can trigger autoimmune leading to the chronic inflammatory demyelinating polyneuropathy. These findings strengthen the possible involvement of short-chain fatty acids in the chronic inflammatory demyelinating polyneuropathy pathogenesis process and could pave new paths in its diagnosis and therapies based on regulation of microbiota dysbiosis.

Keywords

• autoimmune
• gut microbiota
• dysbiosis
• firmicutes
• lachnospiraceae