Al Ameen Journal of Medical Sciences (Apr 2021)
Comparative study of lipid profile and lipid indices in stroke patients and healthy subjects
Abstract
Background: Stroke is a serious, life-threatening medical condition that occurs when the blood supply to part of the brain is cut off. Strokes are a medical emergency and urgent treatment is essential because sooner the person receives treatment for stroke, thereby reducing the serious consequence associated with it. The relationship between atherosclerosis and elevated serum lipids are not well established. Objectives: The study was taken up to decipher whether there is any correlation between lipid profile parameters and pathogenesis of stroke in young and elderly cases of stroke. Methods: The study population consisted of 91 clinically diagnosed stroke cases, of either gender between 25-80 years of age. The relevant clinical history was taken. Around 5 ml of venous blood sample was collected in yellow vacutainer, after a period of 12 hours overnight fasting, then serum was separated. Total cholesterol, triglyceride, high density lipoprotein (HDL-Cholesterol), low density lipoprotein (LDL- cholesterol) and serum creatinine were estimated by on cobas® 6000 analyzer - Roche Diagnostics. Estimation of GFR - eGFR was calculated by using MDRD formula. The atherogenic index and lipid ratios were calculated using the following established formulas. Results: In the study there was increase in LDL- cholesterol (LDL-C) values in old age stroke cases as compared to young age stroke cases. An increase in serum creatinine value was observed in old age cases in comparison to young age cases. In old male stroke cases there was increase in serum cholesterol, triglyceride, LDL- cholesterol , Tc: HDL-cholesterol ratio, CR II, atherogenic coefficient, TG/ HDL-Cholesterol ratio and serum creatinine levels. The study shows higher predisposition to atherogenesis in older age cases as compared to young age stroke cases. There was decrease in HDL-Cholesterol (HDL-C) and eGFR values in older male and female stroke cases in comparison to younger male and female stroke cases. Conclusion: Stroke patients with dyslipidemia need a comprehensive health care approach involving dietician, physician and good biochemistry back up.
