Nature Communications (May 2020)

Segregation of an MSH1 RNAi transgene produces heritable non-genetic memory in association with methylome reprogramming

  • Xiaodong Yang,
  • Robersy Sanchez,
  • Hardik Kundariya,
  • Tom Maher,
  • Isaac Dopp,
  • Rosemary Schwegel,
  • Kamaldeep Virdi,
  • Michael J. Axtell,
  • Sally A. Mackenzie

DOI
https://doi.org/10.1038/s41467-020-16036-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Segregation of an MSH1 RNAi transgene produces non-genetic memory that displays transgenerational inheritance in Arabidopsis. Here, the authors compare memory and non-memory full-sib progenies to show the involvement of DNA methylation reprogramming, involving the RdDM pathway, in transition to a heritable memory state.