Nature Communications (Aug 2017)

Molecular characterization of breast cancer CTCs associated with brain metastasis

  • Debasish Boral,
  • Monika Vishnoi,
  • Haowen N. Liu,
  • Wei Yin,
  • Marc L. Sprouse,
  • Antonio Scamardo,
  • David S. Hong,
  • Tuan Z. Tan,
  • Jean P. Thiery,
  • Jenny C. Chang,
  • Dario Marchetti

DOI
https://doi.org/10.1038/s41467-017-00196-1
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Characterization of CTCs derived from breast cancer patients with brain metastasis (BCBM) may allow for early diagnosis of brain metastasis and/or help for treatment choice and its efficacy. In this study, the authors identify a unique signature, based on patient-derived CTCs transcriptomes, for BCBM- CTCs that is different from primary tumors.