Nature Communications (Oct 2016)
Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals
- Tetsuya Kimura,
- Shigeyuki Nada,
- Noriko Takegahara,
- Tatsusada Okuno,
- Satoshi Nojima,
- Sujin Kang,
- Daisuke Ito,
- Keiko Morimoto,
- Takashi Hosokawa,
- Yoshitomo Hayama,
- Yuichi Mitsui,
- Natsuki Sakurai,
- Hana Sarashina-Kida,
- Masayuki Nishide,
- Yohei Maeda,
- Hyota Takamatsu,
- Daisuke Okuzaki,
- Masaki Yamada,
- Masato Okada,
- Atsushi Kumanogoh
Affiliations
- Tetsuya Kimura
- Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University
- Shigeyuki Nada
- Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University
- Noriko Takegahara
- Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University
- Tatsusada Okuno
- Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University
- Satoshi Nojima
- Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University
- Sujin Kang
- Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University
- Daisuke Ito
- Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University
- Keiko Morimoto
- Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University
- Takashi Hosokawa
- Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University
- Yoshitomo Hayama
- Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University
- Yuichi Mitsui
- Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University
- Natsuki Sakurai
- Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University
- Hana Sarashina-Kida
- Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University
- Masayuki Nishide
- Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University
- Yohei Maeda
- Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University
- Hyota Takamatsu
- Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University
- Daisuke Okuzaki
- DNA-chip Development Center for Infectious Diseases, Research Institute for Microbial Diseases
- Masaki Yamada
- Analytical and Measuring Instruments Division, Global Application Development Center, Shimadzu Corporation
- Masato Okada
- Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University
- Atsushi Kumanogoh
- Department of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University
- DOI
- https://doi.org/10.1038/ncomms13130
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 17
Abstract
The role of nutrient-sensing pathways in regulation of innate immune response is unexplored. Here the authors show that IL-4 activates the amino-acid sensing pathway in macrophages and leads to polarization of anti-inflammatory M2 macrophages via the transcription factor liver X receptor.
