Prediction of protein aggregation on key proteins involved in ischemic stroke

Abstract

Stroke is a genetic condition comprising multiple subtypes and arising from both genic and other multi factors. Genetic basis of stroke is well established through several studies. Advances in integrating sequencing methods and Genome-wide association studies have shown that genetics of stroke is manifested in several genic disorders. Many of the neurodegenerative disorders show aggravated protein aggregation through amyloid formation. Through the protein aggregation prediction, we observed a higher protein disorder in 46 stroke-associated proteins. Also, we observed a large number of aggregation residues distributed as a pattern in multiple regions of these candidate proteins. Overall, we present a study showing that there is a possible interrelationship between protein aggregation and stroke.

Keywords

• Genetic disorder
• Ischemic stroke
• Protein aggregation
• Gene ontology
• KEGG pathway