Cancers (Mar 2024)
Where Morphological and Molecular Classifications Meet: The Role of p53 Immunohistochemistry in the Prognosis of Low-Risk Endometrial Carcinoma (GLAMOUR Study)
- Andrea Puppo,
- Giulio Fraternali Orcioni,
- Valentino Clignon,
- Yuri Musizzano,
- Carla Angela Zavattero,
- Giulia Vocino Trucco,
- Giacomo Maria Benazzo,
- Giuseppe Vizzielli,
- Stefano Restaino,
- Laura Mariuzzi,
- Maria Orsaria,
- Renato Seracchioli,
- Diego Raimondo,
- Linda Bertoldo,
- Stefano Uccella,
- Anna Caliò,
- Giulia Vittori Antisari,
- Simone Garzon,
- Vito Andrea Capozzi,
- Roberto Berretta,
- Francesco Cosentino,
- Alfredo Ercoli,
- Antonio Ieni,
- Martina Arcieri,
- Marcello Ceccaroni,
- Anna Pesci,
- Giulia Mantovani,
- Francesco Bruni,
- Giovanni Roviglione,
- Pio Zeppa,
- Antonio Raffone,
- Marco Camanni,
- Elena Maria Delpiano,
- Claudia Provenza,
- Martina Borghese,
- Giuseppe Migliaretti
Affiliations
- Andrea Puppo
- Department of Gynecology and Obstetrics, Azienda Sanitaria Ospedaliera Santa Croce e Carle, 12100 Cuneo, Italy
- Giulio Fraternali Orcioni
- Department of Pathology, Azienda Sanitaria Ospedaliera Santa Croce e Carle, 12100 Cuneo, Italy
- Valentino Clignon
- Department of Gynecology and Obstetrics, Azienda Sanitaria Ospedaliera Santa Croce e Carle, 12100 Cuneo, Italy
- Yuri Musizzano
- Department of Pathology, Azienda Sanitaria Ospedaliera Santa Croce e Carle, 12100 Cuneo, Italy
- Carla Angela Zavattero
- Department of Pathology, Ospedale Regina Montis Regalis, 12084 Mondovì, Italy
- Giulia Vocino Trucco
- Department of Pathology, Ospedale Regina Montis Regalis, 12084 Mondovì, Italy
- Giacomo Maria Benazzo
- Department of Pathology, Ospedale Regina Montis Regalis, 12084 Mondovì, Italy
- Giuseppe Vizzielli
- Clinic of Obstetrics and Gynecology, “Santa Maria della Misericordia” University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy
- Stefano Restaino
- Clinic of Obstetrics and Gynecology, “Santa Maria della Misericordia” University Hospital, Azienda Ospedaliera Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy
- Laura Mariuzzi
- Institute of Pathology, Academic Hospital “Azienda Sanitaria Universitaria Integrata di Udine”, 33100 Udine, Italy
- Maria Orsaria
- Institute of Pathology, Academic Hospital “Azienda Sanitaria Universitaria Integrata di Udine”, 33100 Udine, Italy
- Renato Seracchioli
- Division of Gynecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy
- Diego Raimondo
- Division of Gynecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy
- Linda Bertoldo
- Division of Gynecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy
- Stefano Uccella
- Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37129 Verona, Italy
- Anna Caliò
- Department of Diagnostic and Public Health, Section of Pathology, University of Verona, 37129 Verona, Italy
- Giulia Vittori Antisari
- Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37129 Verona, Italy
- Simone Garzon
- Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, 37129 Verona, Italy
- Vito Andrea Capozzi
- Department of Medicine and Surgery, University Hospital of Parma, 43126 Parma, Italy
- Roberto Berretta
- Department of Medicine and Surgery, University Hospital of Parma, 43126 Parma, Italy
- Francesco Cosentino
- Department of Medicine and Science of Life “Vincenzo Tibero”, University of Molise UNIMOL, 86100 Campobasso, Italy
- Alfredo Ercoli
- Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, 98125 Messina, Italy
- Antonio Ieni
- Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, University of Messina, 98125 Messina, Italy
- Martina Arcieri
- Department of Biomedical Dental, Morphological and Functional Imaging Science, University of Messina, 98125 Messina, Italy
- Marcello Ceccaroni
- Department of Obstetrics and Gynecology, Gynecologic Oncology and Minimally-Invasive Pelvic Surgery, International School of Surgical Anatomy, IRCCS “Sacro Cuore—Don Calabria” Hospital, 37024 Negrar di Valpolicella, Italy
- Anna Pesci
- Department of Pathology, IRCCS “Sacro Cuore—Don Calabria” Hospital, 37024 Negrar di Valpolicella, Italy
- Giulia Mantovani
- Department of Obstetrics and Gynecology, Gynecologic Oncology and Minimally-Invasive Pelvic Surgery, International School of Surgical Anatomy, IRCCS “Sacro Cuore—Don Calabria” Hospital, 37024 Negrar di Valpolicella, Italy
- Francesco Bruni
- Department of Obstetrics and Gynecology, Gynecologic Oncology and Minimally-Invasive Pelvic Surgery, International School of Surgical Anatomy, IRCCS “Sacro Cuore—Don Calabria” Hospital, 37024 Negrar di Valpolicella, Italy
- Giovanni Roviglione
- Department of Obstetrics and Gynecology, Gynecologic Oncology and Minimally-Invasive Pelvic Surgery, International School of Surgical Anatomy, IRCCS “Sacro Cuore—Don Calabria” Hospital, 37024 Negrar di Valpolicella, Italy
- Pio Zeppa
- Pathology Department, University Hospital San Giovanni e Ruggi d’Aragona, 84131 Salerno, Italy
- Antonio Raffone
- Gynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, 80128 Naples, Italy
- Marco Camanni
- Department of Gynecology and Obstetrics, ASL Citta’ di Torino, 10126 Torino, Italy
- Elena Maria Delpiano
- Department of Gynecology and Obstetrics, ASL Citta’ di Torino, 10126 Torino, Italy
- Claudia Provenza
- Department of Pathology, ASL Citta’ di Torino, Ospedale Giovanni Bosco, 10126 Torino, Italy
- Martina Borghese
- Department of Gynecology and Obstetrics, Azienda Sanitaria Ospedaliera Santa Croce e Carle, 12100 Cuneo, Italy
- Giuseppe Migliaretti
- Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy
- DOI
- https://doi.org/10.3390/cancers16061088
- Journal volume & issue
-
Vol. 16,
no. 6
p. 1088
Abstract
No prospective study has validated molecular classification to guide adjuvant treatment in endometrial cancer (EC), and not even retrospective data are present for patients with morphological low-risk EC. We conducted a retrospective, multicenter, observational study including 370 patients with low-risk endometrioid EC to evaluate the incidence and prognostic role of p53 abnormal expression (p53abn) in this specific subgroup. Among 370 patients, 18 had abnormal expressions of p53 (4.9%). In 13 out of 370 patients (3.6%), recurrences were observed and two were p53abn. When adjusting for median follow-up time, the odds ratio (OR) for recurrence among those with p53abn versus p53 wild type (p53wt) was 5.23—CI 95% 0.98–27.95, p = 0.053. The most common site of recurrence was the vaginal cuff (46.2%). One recurrence occurred within the first year of follow-up, and the patient exhibited p53abn. Both 1-year and 2-year DFS rates were 94.4% and 100% in the p53abn and p53wt groups, respectively. One patient died from the disease and comprised p53wt. No difference in OS was registered between the two groups; the median OS was 21.9 months (16.4–30.1). Larger multicenter studies are needed to tailor the treatment of low-risk EC patients with p53abn. Performing molecular classification on all EC patients might be cost-effective, and despite the limits of our relatively small sample, p53abn patients seem to be at greater risk of recurrence, especially locally and after two years since diagnosis.
Keywords