Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism

Abstract

Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards a MERS-CoV vaccine and highlight potential roadblocks identified from previous attempts to generate coronavirus vaccines.

Keywords

• Middle East respiratory syndrome coronavirus
• severe acute respiratory syndrome coronavirus
• coronavirus spike glycoprotein
• vaccine platforms
• correlates of immunity
• animal models