Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza)
Xiang-Xi Yi,
Jia-Gang Deng,
Cheng-Hai Gao,
Xiao-Tao Hou,
Fei Li,
Zhi-Ping Wang,
Er-Wei Hao,
Yan Xie,
Zheng-Cai Du,
Hui-Xue Huang,
Ri-Ming Huang
Affiliations
Xiang-Xi Yi
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China
Jia-Gang Deng
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China
Cheng-Hai Gao
Guangxi Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China
Xiao-Tao Hou
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China
Fei Li
Guangxi Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China
Zhi-Ping Wang
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China
Er-Wei Hao
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China
Yan Xie
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China
Zheng-Cai Du
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China
Hui-Xue Huang
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China
Ri-Ming Huang
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
Four new cyclohexylideneacetonitrile derivatives 1–4, named menisdaurins B–E, as well as three known cyclohexylideneacetonitrile derivatives—menisdaurin (5), coclauril (6), and menisdaurilide (7)—were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates were elucidated on the basis of extensive spectroscopic analysis. Compounds 1–7 showed anti-Hepatitis B virus (HBV) activities, with EC50 values ranging from 5.1 ± 0.2 μg/mL to 87.7 ± 5.8 μg/mL.
