Interactions Between Nanoparticles and Dendritic Cells: From the Perspective of Cancer Immunotherapy

Jianbo Jia; Yi Zhang; Yan Xin; Cuijuan Jiang; Bing Yan; Bing Yan; Shumei Zhai

doi:10.3389/fonc.2018.00404

Frontiers in Oncology (Sep 2018)

Interactions Between Nanoparticles and Dendritic Cells: From the Perspective of Cancer Immunotherapy

Jianbo Jia,
Yi Zhang,
Yan Xin,
Cuijuan Jiang,
Bing Yan,
Bing Yan,
Shumei Zhai

Affiliations

Jianbo Jia: Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Institute of Environmental Research at Greater Bay, Guangzhou University, Guangzhou, China
Yi Zhang: School of Chemistry and Chemical Engineering, Shandong University, Jinan, China
Yan Xin: School of Chemistry and Chemical Engineering, Shandong University, Jinan, China
Cuijuan Jiang: School of Environmental Science and Engineering, Shandong University, Jinan, China
Bing Yan: Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Institute of Environmental Research at Greater Bay, Guangzhou University, Guangzhou, China
Bing Yan: School of Environmental Science and Engineering, Shandong University, Jinan, China
Shumei Zhai: School of Chemistry and Chemical Engineering, Shandong University, Jinan, China

DOI: https://doi.org/10.3389/fonc.2018.00404
Journal volume & issue: Vol. 8

Abstract

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Dendritic cells (DCs) are the primary antigen-presenting cells and play key roles in the orchestration of the innate and adaptive immune system. Targeting DCs by nanotechnology stands as a promising strategy for cancer immunotherapy. The physicochemical properties of nanoparticles (NPs) influence their interactions with DCs, thus altering the immune outcome of DCs by changing their functions in the processes of maturation, homing, antigen processing and antigen presentation. In this review, we summarize the recent progress in targeting DCs using NPs as a drug delivery carrier in cancer immunotherapy, the recognition of NPs by DCs, and the ways the physicochemical properties of NPs affect DCs' functions. Finally, the molecular pathways in DCs that are affected by NPs are also discussed.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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