Reactive oxygen species-responsive and Raman-traceable hydrogel combining photodynamic and immune therapy for postsurgical cancer treatment

Yiyi Zhang; Sidan Tian; Liping Huang; Yanan Li; Yuan Lu; Hongyu Li; Guiping Chen; Fanling Meng; Gang L. Liu; Xiangliang Yang; Jiasheng Tu; Chunmeng Sun; Liang Luo

doi:10.1038/s41467-022-32160-z

Nature Communications (Aug 2022)

Reactive oxygen species-responsive and Raman-traceable hydrogel combining photodynamic and immune therapy for postsurgical cancer treatment

Yiyi Zhang,
Sidan Tian,
Liping Huang,
Yanan Li,
Yuan Lu,
Hongyu Li,
Guiping Chen,
Fanling Meng,
Gang L. Liu,
Xiangliang Yang,
Jiasheng Tu,
Chunmeng Sun,
Liang Luo

Affiliations

Yiyi Zhang: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Sidan Tian: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Liping Huang: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Yanan Li: NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University
Yuan Lu: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Hongyu Li: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Guiping Chen: Bruker (Beijing) Scientific Technology Company Limited, Shanghai Branch
Fanling Meng: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Gang L. Liu: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Xiangliang Yang: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Jiasheng Tu: NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University
Chunmeng Sun: NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University
Liang Luo: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology

DOI: https://doi.org/10.1038/s41467-022-32160-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Combined immune checkpoint blockade (ICB) and photodynamic therapies have huge potential but suffer from possible damage of the antibodies. Here, the authors create a ROS-responsive hydrogel that protects the ICB antibodies and allows for sustained co-delivery and demonstrate restrained regrowth of tumours in vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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