The prevalence of allelic variants of VKORC1, CYP2C9 and CYP4F2 genes in Zaporizhzhia region population

Abstract

Objective – to determine the allele frequency of VKORC1, CYP2C9 and CYP4F2 genes in Zaporizhzhia region population. Materials and methods. We investigated 94 individuals at the age of 56 (47; 62) years (men – 23, women – 71) who underwent preventive examination at the “Health” Diagnostic Center based on the ESMC “University Clinic” of the Zaporizhzhya State Medical University. To investigate the polymorphism of CYP2C9, CYP4F2, VKORC1 genes the polymorphic chain reaction method was used. Results. It was established that in Zaporizhzhia region population, the frequency of detection of CYP2C9*2 polymorphic variants is: C/C – 80.9 %, C/T – 19.1 %, T/T – not observed; CYP2C9*3: A/A – 89.0 %, A/C – 11.0 %, C/C – not observed; CYP4F2: C/C – 50.0%, C/T – 40.4 %, T/T – 9.6 %; VKORC: 1 G/G – 40.4 %, G/A – 49.0 %, A/A – 10.6 %. It was discovered that the frequency of registration of polymorphic variants of genes CYP2C9, CYP4F2, VKORC1 varies in different geographic regions, that justifies the expediency of determining these genotypes for each population. Conclusions. The implementation of pharmacogenetic testing based on the polymorphism of genes that affect warfarin metabolism for the warfarine dose titration is perspective.

Keywords

• pharmacogenetics
• warfarin
• genotype
• prevalence