Фармакокинетика и Фармакодинамика (Oct 2019)

Neuroprotective effect of myoinositol on the cellular model of glutamate stress as a basis for the prevention of disorders of intrauterine development of the brain

  • A. G. Kalacheva,
  • I. Yu. Torshin,
  • E. V. Stelmashuk,
  • E. E. Genrikhs,
  • O. P. Alexandrova,
  • L. G. Khaspekov,
  • O. A. Gromova

DOI
https://doi.org/10.24411/2587-7836-2018-10018.
Journal volume & issue
Vol. 0, no. 3
pp. 9 – 20

Abstract

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Myoinositol is the basis for the synthesis of an important group of signal molecules, inositolphosphates, which mediate signal transmission from receptors of growth factors and neurotransmitters. Grants myo-Inositol promote the prevention of folate-resistant defects and neuroprotection of the fetal brain ischemia. The paper presents the results of a study of the effects of myoinositol on the growth of cerebellar neurons in culture under glutamate stress. It is shown that the effects of myoinositol on the survival of neurons (+17 %) exceed the effects of drugs that are usually used for neuroprotection (peptide extracts - + 10 %, choline preparations - no more than 3 %). Confirmed in the present work, a direct neuroprotective effect of myo-Inositol indicates the importance of the use of myo-Inositol during pregnancy with the aim of neuroprotection of the fetal brain.

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