A redox-neutral catechol synthesis

Qian Wu; Dingyuan Yan; Ying Chen; Ting Wang; Feng Xiong; Wei Wei; Yi Lu; Wei-Yin Sun; Jie Jack Li; Jing Zhao

doi:10.1038/ncomms14227

Nature Communications (Jan 2017)

A redox-neutral catechol synthesis

Qian Wu,
Dingyuan Yan,
Ying Chen,
Ting Wang,
Feng Xiong,
Wei Wei,
Yi Lu,
Wei-Yin Sun,
Jie Jack Li,
Jing Zhao

Affiliations

Qian Wu: Guangdong Key Lab of Nano-Micro Material Research, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School
Dingyuan Yan: Department of Chemistry, State Key Laboratory of Coordination Chemistry, Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Collaborative Innovation Centre of Chemistry for Life Sciences, Nanjing University
Ying Chen: Guangdong Key Lab of Nano-Micro Material Research, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School
Ting Wang: School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School
Feng Xiong: Department of Chemistry, State Key Laboratory of Coordination Chemistry, Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Collaborative Innovation Centre of Chemistry for Life Sciences, Nanjing University
Wei Wei: Department of Chemistry, State Key Laboratory of Coordination Chemistry, Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Collaborative Innovation Centre of Chemistry for Life Sciences, Nanjing University
Yi Lu: Department of Chemistry, State Key Laboratory of Coordination Chemistry, Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Collaborative Innovation Centre of Chemistry for Life Sciences, Nanjing University
Wei-Yin Sun: Department of Chemistry, State Key Laboratory of Coordination Chemistry, Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Collaborative Innovation Centre of Chemistry for Life Sciences, Nanjing University
Jie Jack Li: Department of Chemistry, University of San Francisco
Jing Zhao: Guangdong Key Lab of Nano-Micro Material Research, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School

DOI: https://doi.org/10.1038/ncomms14227
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

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Catechols are common structural motifs in bioactive molecules and synthetic building blocks. Here the authors report a method to convert phenol derivatives into catechols via an iridium-catalysed redox-neutral C–H hydroxylation, giving diversely substituted products under mild conditions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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