Frontiers in Pharmacology (Nov 2022)

NMI: a potential biomarker for tumor prognosis and immunotherapy

  • Teng He,
  • Yinbiao Qiao,
  • Qi Yang,
  • Jie Chen,
  • Yongyuan Chen,
  • Yongyuan Chen,
  • Xiaoke Chen,
  • Xiaoke Chen,
  • Zhixing Hao,
  • Zhixing Hao,
  • Mingjie Lin,
  • Mingjie Lin,
  • Zheyu Shao,
  • Zheyu Shao,
  • Pin Wu,
  • Pin Wu,
  • Feng Xu

DOI
https://doi.org/10.3389/fphar.2022.1047463
Journal volume & issue
Vol. 13

Abstract

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N-Myc and STAT Interactor protein (NMI) is an interferon inducible protein participating in various cellular activities, and is widely involved in the process of tumorigenesis and progression. Studies have shown that the loss of NMI expression in breast cancer can promote its progression by inducing epithelial-mesenchymal transition (EMT). However, the expression level of NMI in other tumors and its impact on immune cell infiltration, patient prognosis, and drug treatment are still unclear. Here, we analyzed the role of NMI in pan-cancer through multiple omics data. We found that NMI was abnormally expressed in a variety of tumor tissues. The expression of NMI was closely related to the unique molecular and immunotyping, diagnosis and prognosis of various tumor tissues. In addition, we identified the main proteins that interact with NMI, and focused on the relationship between the clinical parameters of lower grade glioma (LGG) and NMI expression. Subsequently, we found that the expression of NMI was correlated with the infiltration of multiple immune cells and the expression of immune checkpoints. Finally, we also found that the expression of NMI was correlated with the sensitivity to multiple antitumor drugs. In conclusion, our comprehensive pan-cancer analysis of NMI revealed that it is a potential molecular marker for tumor diagnosis and treatment, plays an important role in tumor immunity, and is a promising molecular target for cancer treatment.

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