Nature Communications (May 2016)
Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer
- Akash K. Kaushik,
- Ali Shojaie,
- Katrin Panzitt,
- Rajni Sonavane,
- Harene Venghatakrishnan,
- Mohan Manikkam,
- Alexander Zaslavsky,
- Vasanta Putluri,
- Vihas T. Vasu,
- Yiqing Zhang,
- Ayesha S. Khan,
- Stacy Lloyd,
- Adam T. Szafran,
- Subhamoy Dasgupta,
- David A. Bader,
- Fabio Stossi,
- Hangwen Li,
- Susmita Samanta,
- Xuhong Cao,
- Efrosini Tsouko,
- Shixia Huang,
- Daniel E. Frigo,
- Lawrence Chan,
- Dean P. Edwards,
- Benny A. Kaipparettu,
- Nicholas Mitsiades,
- Nancy L. Weigel,
- Michael Mancini,
- Sean E. McGuire,
- Rohit Mehra,
- Michael M. Ittmann,
- Arul M. Chinnaiyan,
- Nagireddy Putluri,
- Ganesh S. Palapattu,
- George Michailidis,
- Arun Sreekumar
Affiliations
- Akash K. Kaushik
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Ali Shojaie
- Department of Biostatistics, University of Washington
- Katrin Panzitt
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Rajni Sonavane
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Harene Venghatakrishnan
- Comprehensive Cancer Center, University of Michigan
- Mohan Manikkam
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Alexander Zaslavsky
- Comprehensive Cancer Center, University of Michigan
- Vasanta Putluri
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Vihas T. Vasu
- Department of Zoology, Maharaja Sayajirao University of Baroda
- Yiqing Zhang
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Ayesha S. Khan
- Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston
- Stacy Lloyd
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Adam T. Szafran
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Subhamoy Dasgupta
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- David A. Bader
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Fabio Stossi
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Hangwen Li
- Comprehensive Cancer Center, University of Michigan
- Susmita Samanta
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Xuhong Cao
- Comprehensive Cancer Center, University of Michigan
- Efrosini Tsouko
- Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston
- Shixia Huang
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Daniel E. Frigo
- Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston
- Lawrence Chan
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Dean P. Edwards
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Benny A. Kaipparettu
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Nicholas Mitsiades
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Nancy L. Weigel
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Michael Mancini
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Sean E. McGuire
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Rohit Mehra
- Comprehensive Cancer Center, University of Michigan
- Michael M. Ittmann
- Department of Pathology and Immunology, Baylor College of Medicine
- Arul M. Chinnaiyan
- Comprehensive Cancer Center, University of Michigan
- Nagireddy Putluri
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- Ganesh S. Palapattu
- Comprehensive Cancer Center, University of Michigan
- George Michailidis
- Department of Statistics, University of Michigan
- Arun Sreekumar
- Department of Molecular and Cellular Biology and Alkek Center for Molecular Discovery, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/ncomms11612
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
The molecular alterations driving anti-androgen resistance in prostate cancer are unclear. Here, the authors show, using a network-based approach, that inhibition of the hexosamine biosynthetic pathway is necessary to develop resistance and that increasing the activity of the pathway enhances the anti-androgen response.
