Association between kidney function and Framingham global cardiovascular disease risk score: a Chinese longitudinal study.

Abstract

BACKGROUND: Chronic kidney disease (CKD) is generally considered an independent risk factor for cardiovascular disease (CVD) development, but rates in individuals with estimated glomerular filtration rate (eGFR) >60 ml/min/1.73 m(2) are uncertain. The Framingham global CVD risk score (FRS) equation is a widely accepted tool used to predict CVD risk in the general population. The purpose of the present study was to examine whether an association exists between eGFR and FRS in a Chinese population with no CKD or CVD. METHODS: A total of 333 participants were divided into three groups based on FRS. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and CKD-EPI equation for Asians (CKD-EPI-ASIA) were used to measure eGFR. RESULTS: A significant inverse association between eGFR and FRS was confirmed with Pearson correlation coefficients of -0.669, -0.698 (eGFR(CKD-EPI), P0.05; similar results according to the CKD-EPI-ASIA equation). In the low- or moderate-risk new-groups, this association became stronger with increased FRS (eGFR(CKD-EPI)-ASIA, r = -0557, -0.622 or -0.326, -0.329, P60 ml/min/1.73 m(2).