Nature Communications (Sep 2021)

CloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data

  • Judith Abécassis,
  • Fabien Reyal,
  • Jean-Philippe Vert

DOI
https://doi.org/10.1038/s41467-021-24992-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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Intratumour heterogeneity (ITH) and mutational signatures are typically analysed separately, even though they are not necessarily independent. Here, the authors present CloneSig, a tool for the joint estimation of ITH and mutational signatures, with which they analyse the TCGA and PCAWG datasets.