Nature Communications (Nov 2018)

Differential lateral and basal tension drive folding of Drosophila wing discs through two distinct mechanisms

  • Liyuan Sui,
  • Silvanus Alt,
  • Martin Weigert,
  • Natalie Dye,
  • Suzanne Eaton,
  • Florian Jug,
  • Eugene W. Myers,
  • Frank Jülicher,
  • Guillaume Salbreux,
  • Christian Dahmann

DOI
https://doi.org/10.1038/s41467-018-06497-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Epithelial folding has mainly been linked to forces acting in the apical actomyosin network of cells. Here, the authors show using live imaging that two distinct mechanisms, changes in basal surface tension and changes in lateral surface tension, drive the formation of two folds in the Drosophila wing disc.