Nature Communications (Aug 2019)
Distinct methylation levels of mature microRNAs in gastrointestinal cancers
- Masamitsu Konno,
- Jun Koseki,
- Ayumu Asai,
- Akira Yamagata,
- Teppei Shimamura,
- Daisuke Motooka,
- Daisuke Okuzaki,
- Koichi Kawamoto,
- Tsunekazu Mizushima,
- Hidetoshi Eguchi,
- Shuji Takiguchi,
- Taroh Satoh,
- Koshi Mimori,
- Takahiro Ochiya,
- Yuichiro Doki,
- Ken Ofusa,
- Masaki Mori,
- Hideshi Ishii
Affiliations
- Masamitsu Konno
- Department of Frontier Science for Cancer and Chemotherapy, Graduate School of Medicine, Osaka University
- Jun Koseki
- Department of Cancer Profiling Discovery/ Medical Data Science, Graduate School of Medicine, Osaka University
- Ayumu Asai
- Department of Frontier Science for Cancer and Chemotherapy, Graduate School of Medicine, Osaka University
- Akira Yamagata
- Prophoenix Division, Food and Life-Science Laboratory, Idea Consultants, Inc., Osaka-city
- Teppei Shimamura
- Division of Systems Biology, Nagoya University Graduate School of Medicine
- Daisuke Motooka
- Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University
- Daisuke Okuzaki
- Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University
- Koichi Kawamoto
- Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
- Tsunekazu Mizushima
- Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
- Hidetoshi Eguchi
- Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
- Shuji Takiguchi
- Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
- Taroh Satoh
- Department of Frontier Science for Cancer and Chemotherapy, Graduate School of Medicine, Osaka University
- Koshi Mimori
- Department of Surgery, Kyushu University Beppu Hospital
- Takahiro Ochiya
- Division of Molecular and Cellular Medicine, National Cancer Center Research Institute
- Yuichiro Doki
- Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
- Ken Ofusa
- Prophoenix Division, Food and Life-Science Laboratory, Idea Consultants, Inc., Osaka-city
- Masaki Mori
- Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University
- Hideshi Ishii
- Department of Cancer Profiling Discovery/ Medical Data Science, Graduate School of Medicine, Osaka University
- DOI
- https://doi.org/10.1038/s41467-019-11826-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 7
Abstract
In cancer it is assumed that microRNAs recognise and regulate their targets uniformly. Here, the authors show that in gastrointestinal cancers methylation of microRNAs may impact their stability, and that levels of microRNA methylation are distinct in pancreatic cancer patients compared to healthy controls with potential diagnostic implications.
