Marine Drugs (Nov 2011)

Brominated Compounds from Marine Sponges of the Genus Aplysina and a Compilation of Their 13C NMR Spectral Data

  • Jose Maria Barbosa-Filho,
  • Celidarque da Silva Dias,
  • Luis Cezar Rodrigues,
  • Narlize Silva Lira,
  • Petronio Filgueiras de Athayde-Filho,
  • Emidio V. L. da Cunha,
  • Josean Fechine Tavares,
  • Ricardo Carneiro Montes,
  • Marcelo Sobral da Silva

DOI
https://doi.org/10.3390/md9112316
Journal volume & issue
Vol. 9, no. 11
pp. 2316 – 2368

Abstract

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Aplysina is the best representative genus of the family Aplysinidae. Halogenated substances are its main class of metabolites. These substances contribute greatly to the chemotaxonomy and characterization of the sponges belonging to this genus. Due to their pharmacological activities, these alkaloids are of special interest. The chemistry of halogenated substances and of the alkaloids has long been extensively studied in terrestrial organisms, while the number of marine organisms studied has just started to increase in the last decades. This review describes 101 halogenated substances from 14 species of Aplysina from different parts of the world. These substances can be divided into the following classes: bromotyramines (A), cavernicolins (B), hydroverongiaquinols (C), bromotyrosineketals (D), bromotyrosine lactone derivatives (E), oxazolidones (F), spiroisoxazolines (G), verongiabenzenoids (H), verongiaquinols (I), and dibromocyclohexadienes (J). A compilation of their 13C NMR data is also part of the review. For this purpose 138 references were consulted.

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