X-ray structure of a carpet-like antimicrobial defensin–phospholipid membrane disruption complex

Michael Järvå; Fung T. Lay; Thanh Kha Phan; Cassandra Humble; Ivan K. H. Poon; Mark R. Bleackley; Marilyn A. Anderson; Mark D. Hulett; Marc Kvansakul

doi:10.1038/s41467-018-04434-y

Nature Communications (May 2018)

X-ray structure of a carpet-like antimicrobial defensin–phospholipid membrane disruption complex

Michael Järvå,
Fung T. Lay,
Thanh Kha Phan,
Cassandra Humble,
Ivan K. H. Poon,
Mark R. Bleackley,
Marilyn A. Anderson,
Mark D. Hulett,
Marc Kvansakul

Affiliations

Michael Järvå: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
Fung T. Lay: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
Thanh Kha Phan: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
Cassandra Humble: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
Ivan K. H. Poon: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
Mark R. Bleackley: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
Marilyn A. Anderson: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
Mark D. Hulett: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
Marc Kvansakul: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University

DOI: https://doi.org/10.1038/s41467-018-04434-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Defensins are cationic antimicrobial peptides that permeabilize membranes of pathogens presumably via the assembly of defensin–lipid oligomers. Here authors provide evidence for this by solving the crystal structure of a plant defensin in an oligomeric state with phospholipids.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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