Frontiers in Microbiology (Jun 2020)
Sorbicillinoid Derivatives From Sponge-Derived Fungus Trichoderma reesei (HN-2016-018)
- Saif Ur Rehman,
- Saif Ur Rehman,
- Saif Ur Rehman,
- Saif Ur Rehman,
- Lu-Jia Yang,
- Lu-Jia Yang,
- Lu-Jia Yang,
- Ya-Hui Zhang,
- Ya-Hui Zhang,
- Ya-Hui Zhang,
- Jing-Shuai Wu,
- Jing-Shuai Wu,
- Jing-Shuai Wu,
- Ting Shi,
- Ting Shi,
- Ting Shi,
- Waqas Haider,
- Waqas Haider,
- Waqas Haider,
- Chang-Lun Shao,
- Chang-Lun Shao,
- Chang-Lun Shao,
- Chang-Yun Wang,
- Chang-Yun Wang,
- Chang-Yun Wang
Affiliations
- Saif Ur Rehman
- Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
- Saif Ur Rehman
- Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China
- Saif Ur Rehman
- Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China
- Saif Ur Rehman
- Department of Pharmacy, Faculty of Medical and Health Sciences, University of Poonch Rawalakot, Rawalakot, Pakistan
- Lu-Jia Yang
- Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
- Lu-Jia Yang
- Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China
- Lu-Jia Yang
- Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China
- Ya-Hui Zhang
- Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
- Ya-Hui Zhang
- Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China
- Ya-Hui Zhang
- Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China
- Jing-Shuai Wu
- Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
- Jing-Shuai Wu
- Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China
- Jing-Shuai Wu
- Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China
- Ting Shi
- Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
- Ting Shi
- Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China
- Ting Shi
- Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China
- Waqas Haider
- Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
- Waqas Haider
- Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China
- Waqas Haider
- Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China
- Chang-Lun Shao
- Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
- Chang-Lun Shao
- Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China
- Chang-Lun Shao
- Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China
- Chang-Yun Wang
- Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
- Chang-Yun Wang
- Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, China
- Chang-Yun Wang
- Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China
- DOI
- https://doi.org/10.3389/fmicb.2020.01334
- Journal volume & issue
-
Vol. 11
Abstract
Six new sorbicillinoids, trichoreeseione A (1) and B (2), trichodermolide B (3), 13-hydroxy-trichodermolide (4), 24-hydroxy-trichodimerol (5), 15-hydroxy-bisvertinol (7), together with three known analogs, trichodimerol (6), 24-hydroxy-bisvertinol (8), and bisvertinol (9), were isolated from the sponge-derived fungus Trichoderma reesei (HN-2016-018). Their structures including absolute configurations were elucidated by analysis of NMR, MS data, and calculated ECD spectra. Compounds 1 and 2 with a characteristic naphthalene-trione ring were firstly reported in sorbicillinoid family. Compounds 3 and 4 were two rare sorbicillinoids containing a unique bicycle [3.2.1] lactone skeleton, while 3 with a propan-2-one moiety was also recorded first time in this family. Compound 5 displayed cytotoxic activity against A549, MCF-7, and HCT116 cell lines with the IC50 values of 5.1, 9.5, and 13.7 μM, respectively.
Keywords
