Nature Communications (Sep 2021)

Structural basis for UFM1 transfer from UBA5 to UFC1

  • Manoj Kumar,
  • Prasanth Padala,
  • Jamal Fahoum,
  • Fouad Hassouna,
  • Tomer Tsaban,
  • Guy Zoltsman,
  • Sayanika Banerjee,
  • Einav Cohen-Kfir,
  • Moshe Dessau,
  • Rina Rosenzweig,
  • Michail N. Isupov,
  • Ora Schueler-Furman,
  • Reuven Wiener

DOI
https://doi.org/10.1038/s41467-021-25994-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

Ufmylation is a well-established ubiquitin-like protein modification, but its mechanism is largely unclear. Here, the authors present a crystal structure of the ufmylation-specific E1-E2 complex, revealing differences to the ubiquitination machinery and mechanistic details of the ufmylation process.