R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon

Christine Harnack; Hilmar Berger; Agne Antanaviciute; Ramon Vidal; Sascha Sauer; Alison Simmons; Thomas F. Meyer; Michael Sigal

doi:10.1038/s41467-019-12349-5

Nature Communications (Sep 2019)

R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon

Christine Harnack,
Hilmar Berger,
Agne Antanaviciute,
Ramon Vidal,
Sascha Sauer,
Alison Simmons,
Thomas F. Meyer,
Michael Sigal

Affiliations

Christine Harnack: Medical Department, Division of Gastroenterology and Hepatology, Charité University Medicine
Hilmar Berger: Department of Molecular Biology, Max Planck Institute for Infection Biology
Agne Antanaviciute: Nuffield Department of Medicine and MRC Human Immunology Unit, University of Oxford
Ramon Vidal: Max Delbrück Center
Sascha Sauer: Max Delbrück Center
Alison Simmons: Nuffield Department of Medicine and MRC Human Immunology Unit, University of Oxford
Thomas F. Meyer: Department of Molecular Biology, Max Planck Institute for Infection Biology
Michael Sigal: Medical Department, Division of Gastroenterology and Hepatology, Charité University Medicine

DOI: https://doi.org/10.1038/s41467-019-12349-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Epithelial turnover in the colon requires stem cells in the crypt that express the R-spondin receptor Lgr5. Here, the authors show that regeneration after colon injury involving loss of Lgr5+ and Axin2+ cells requires stromal derived Rspo3-dependent reprogramming of Lgr4+ differentiated cells, including Krt20+ enterocytes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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