Association between base excess and 28-day mortality in sepsis patients: A secondary analysis based on the MIMIC- IV database
Jia Yuan,
Xu Liu,
Ying Liu,
Wei Li,
Xianjun Chen,
Qiming Chen,
Chuan Xiao,
Ying Wan,
Shuwen Li,
Qing Li,
Lu Li,
Juan He,
Lu Chen,
Feng Shen
Affiliations
Jia Yuan
Department of Intensive Care Unit, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, Guizhou Province, China
Xu Liu
Department of Intensive Care Unit, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, Guizhou Province, China
Ying Liu
Department of Intensive Care Unit, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, Guizhou Province, China
Wei Li
Department of Intensive Care Unit, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, Guizhou Province, China
Xianjun Chen
Department of Intensive Care Unit, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, Guizhou Province, China
Qiming Chen
Department of Intensive Care Unit, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, Guizhou Province, China
Chuan Xiao
Department of Intensive Care Unit, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, Guizhou Province, China
Ying Wan
Department of Good Clinical Practice, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, Guizhou Province, China
Shuwen Li
Department of Intensive Care Unit, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, Guizhou Province, China
Qing Li
Department of Intensive Care Unit, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, Guizhou Province, China
Lu Li
Department of Intensive Care Unit, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, Guizhou Province, China
Juan He
Department of Intensive Care Unit, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, Guizhou Province, China
Lu Chen
Department of Good Clinical Practice, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, Guizhou Province, China
Feng Shen
Department of Intensive Care Unit, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, Guizhou Province, China; Corresponding author.
Objective: The relationship between base excess (BE) and 28-day death in sepsis patients remains to be elucidated. The aim of our clinical study is to explore the association of BE with 28-day mortality in patients with sepsis by using a large sample, multicenter Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Methods: We extracted the data of 35,010 patients with sepsis from the MIMIC-IV database, in which we used BE as an exposure variable and the 28-day mortality as an outcome variable, respectively, so as to explore the impact of BE on the 28-day mortality of patients with sepsis after adjusting for covariates. Results: BE and the 28-day mortality of patients with sepsis appeared to have a U-shaped relationship. The calculated inflection points were −2.5 mEq/L and 1.9 mEq/L, respectively. Our data demonstrated that BE was negatively associated with 28-day mortality in the range of −41.0 mEq/L to −2.5 mEq/L (odds ratio: 0.95; 95% confidence intervals (95%CI): 0.93 to 0.96), p < 0.0001. When BE was in the range of 1.9 mEq/L to 55.5 mEq/L, however, a positive association existed between BE and 28-day mortality of patients with sepsis (odds ratio: 1.03; 95% CI: 1.00 to 1.05; p < 0.05). Conclusion: The BE levels have a U-shaped relationship with the 28-day mortality in patients with sepsis, in which the mortality of patients will gradually decrease with a BE value from −41.0 mEq/L to −2.5 mEq/L, while the mortality will increase with a BE value from 1.9 mEq/L to 55.5 mEq/L.
