TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival

Lele Zhu; Xiaoping Xie; Lingyun Zhang; Hui Wang; Zuliang Jie; Xiaofei Zhou; Jianhong Shi; Shuli Zhao; Boxiang Zhang; Xuhong Cheng; Shao-Cong Sun

doi:10.1038/s41467-018-05097-5

Nature Communications (Jul 2018)

TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival

Lele Zhu,
Xiaoping Xie,
Lingyun Zhang,
Hui Wang,
Zuliang Jie,
Xiaofei Zhou,
Jianhong Shi,
Shuli Zhao,
Boxiang Zhang,
Xuhong Cheng,
Shao-Cong Sun

Affiliations

Lele Zhu: Department of Immunology, The University of Texas MD Anderson Cancer Center
Xiaoping Xie: Department of Immunology, The University of Texas MD Anderson Cancer Center
Lingyun Zhang: Department of Immunology, The University of Texas MD Anderson Cancer Center
Hui Wang: Department of Immunology, The University of Texas MD Anderson Cancer Center
Zuliang Jie: Department of Immunology, The University of Texas MD Anderson Cancer Center
Xiaofei Zhou: Department of Immunology, The University of Texas MD Anderson Cancer Center
Jianhong Shi: Department of Immunology, The University of Texas MD Anderson Cancer Center
Shuli Zhao: Department of Immunology, The University of Texas MD Anderson Cancer Center
Boxiang Zhang: Department of Immunology, The University of Texas MD Anderson Cancer Center
Xuhong Cheng: Department of Immunology, The University of Texas MD Anderson Cancer Center
Shao-Cong Sun: Department of Immunology, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-018-05097-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Interleukin-15 (IL-15) regulates the homeostasis of many immune cell types, including natural killer T (NKT) cells, but the underlying mechanism is not completely clear. Here the authors analyse Tbkbp1-deficient mice and show that IL-15 induces Tbkbp1-dependent autophagy to modulate NKT survival.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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