ELABORATION OF PHYSICAL AND CHEMICAL New METHODS OF DIOXOINDOLINONE ANALYSIS – POTENTIAL AUTOHTON ANTIDEPRESSIVE DRUG

Abstract

Mental illnesses are a current public health problem, as their incidence and prevalence are constantly increasing. Depressive disorders are some of the most common psychiatric disorders. According to WHO data, the number of people suffering from depression has increased by 18 percent over the last decade, globally, reaching 322 million. Mental disorder therapy requires continuous updating. In the Laboratory of Organic synthesis and biopharmaceuticals of the Institute of Chemistry was synthesized a new compound, derivative of izatin – Dioxoindolinone – with anxiolytic and antidepressant action (according to preliminary studies). This article represents the results obtained from the study of the physical, chemical and physico-chemical properties of the studied compound: solubility, aspect of the solution, determination of the limit of non-specific impurities, losses through drying, determination of the melting point, as well as the elaboration of chemical reactions for identification. The results of the following research will be used for the future elaboration of the Analytical Documentation of Normation for Dioxoindolinone.

Keywords

• isatin
• anxiety
• depression
• methods of analysis
• solubility
• aspect of the solution
• melting point
• losses through drying
• non-specific impurities
• chemical reactions for identification