Nature Communications (Jun 2018)
Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48
- Georgia Velimezi,
- Lydia Robinson-Garcia,
- Francisco Muñoz-Martínez,
- Wouter W. Wiegant,
- Joana Ferreira da Silva,
- Michel Owusu,
- Martin Moder,
- Marc Wiedner,
- Sara Brin Rosenthal,
- Kathleen M. Fisch,
- Jason Moffat,
- Jörg Menche,
- Haico van Attikum,
- Stephen P. Jackson,
- Joanna I. Loizou
Affiliations
- Georgia Velimezi
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Lydia Robinson-Garcia
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Francisco Muñoz-Martínez
- The Gurdon Institute and Department of Biochemistry, University of Cambridge
- Wouter W. Wiegant
- Department of Human Genetics, Leiden University Medical Center, Leiden
- Joana Ferreira da Silva
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Michel Owusu
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Martin Moder
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Marc Wiedner
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Sara Brin Rosenthal
- Center for Computational Biology & Bioinformatics, Department of Medicine, University of California, San Diego
- Kathleen M. Fisch
- Center for Computational Biology & Bioinformatics, Department of Medicine, University of California, San Diego
- Jason Moffat
- Donnelly Centre and Banting and Best Department of Medical Research, University of Toronto
- Jörg Menche
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Haico van Attikum
- Department of Human Genetics, Leiden University Medical Center, Leiden
- Stephen P. Jackson
- The Gurdon Institute and Department of Biochemistry, University of Cambridge
- Joanna I. Loizou
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-018-04649-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Fanconi anemia is a rare disease caused by defective DNA interstrand crosslink repair. Here the authors observe that USP48 deficiencies reduce chromosomal instability in FA-defective cells, suggesting it might be a potential therapeutic target.
