Optical tweezing of microparticles and cells using silicon-photonics-based optical phased arrays

Abstract

Abstract Integrated optical tweezers have the potential to enable highly-compact, low-cost, mass-manufactured, and broadly-accessible optical manipulation when compared to standard bulk-optical tweezers. However, integrated demonstrations to date have been fundamentally limited to micron-scale standoff distances and, often, passive trapping functionality, making them incompatible with many existing applications and significantly limiting their utility, especially for biological studies. In this work, we demonstrate optical trapping and tweezing using an integrated OPA for the first time, increasing the standoff distance of integrated optical tweezers by over two orders of magnitude compared to prior demonstrations. First, we demonstrate trapping of polystyrene microspheres 5 mm above the surface of the chip and calibrate the trap force. Next, we show tweezing of polystyrene microspheres in one dimension by non-mechanically steering the trap by varying the input laser wavelength. Finally, we use the OPA tweezers to demonstrate, to the best of our knowledge, the first cell experiments using single-beam integrated optical tweezers, showing controlled deformation of mouse lymphoblast cells. This work introduces a new modality for integrated optical tweezers, significantly expanding their utility and compatibility with existing applications, especially for biological experiments.