TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses

Tatjana Lalic; Aiste Steponenaite; Liting Wei; Sridhar R. Vasudevan; Alistair Mathie; Stuart N. Peirson; Gurprit S. Lall; M. Zameel Cader

doi:10.1038/s41467-020-17978-9

Nature Communications (Sep 2020)

TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses

Tatjana Lalic,
Aiste Steponenaite,
Liting Wei,
Sridhar R. Vasudevan,
Alistair Mathie,
Stuart N. Peirson,
Gurprit S. Lall,
M. Zameel Cader

Affiliations

Tatjana Lalic: Translational Molecular Neuroscience Group, Weatherall Institute of Molecular Medicine, Nuffield Department of Clinical Neurosciences, University of Oxford
Aiste Steponenaite: Medway School of Pharmacy, University of Kent and University of Greenwich
Liting Wei: Translational Molecular Neuroscience Group, Weatherall Institute of Molecular Medicine, Nuffield Department of Clinical Neurosciences, University of Oxford
Sridhar R. Vasudevan: Department of Pharmacology, University of Oxford
Alistair Mathie: Medway School of Pharmacy, University of Kent and University of Greenwich
Stuart N. Peirson: Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford
Gurprit S. Lall: Medway School of Pharmacy, University of Kent and University of Greenwich
M. Zameel Cader: Translational Molecular Neuroscience Group, Weatherall Institute of Molecular Medicine, Nuffield Department of Clinical Neurosciences, University of Oxford

DOI: https://doi.org/10.1038/s41467-020-17978-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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The suprachiasmatic nucleus (SCN) ensures rhythmic electrical activity that varies between day and night to determine circadian behaviours. The authors show that TRESK channels provide a feedback mechanism to maintain the SCN in the appropriate state for nocturnal light-induced behavioural changes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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