Research progress on the role of IgG N-glycosylation modification in diabetic retinopathy

ZHANG Yixin, CAI Shanjun, LI Zhili, YU Weihong, ZHANG Hua

doi:10.16352/j.issn.1001-6325.2023.03.509

Jichu yixue yu linchuang (Mar 2023)

Research progress on the role of IgG N-glycosylation modification in diabetic retinopathy

ZHANG Yixin, CAI Shanjun, LI Zhili, YU Weihong, ZHANG Hua

Affiliations

ZHANG Yixin, CAI Shanjun, LI Zhili, YU Weihong, ZHANG Hua: 1. Department of Ophthalmology, Affiliated Hospital of Zunyi Medical University, Zunyi 563003;;2. Department of Biophysics and Structural Biology, Institute of Basic Medical Sciences CAMS, School of Basic Medicine PUMC, Beijing 100005;;3. Department of Ophthalmology, Peking Union Medical College Hospital;;4. College of Continuing Education, CAMS ＆ PUMC, Beijing 100730, China

DOI: https://doi.org/10.16352/j.issn.1001-6325.2023.03.509
Journal volume & issue: Vol. 43, no. 3
pp. 509 – 513

Abstract

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Diabetic retinopathy (DR) is an immune-inflammatory disease and immunoglobulin G(IgG) N-glycosylation modifications are closely associated with DR. Among them, the modification of galactosylation, fucosylation, sialylation and bisecting N-acetylglucosamine of IgG changed has been proved to be predisposing factor to stimulate inflammation and related retinopathy.

diabetic retinopathy|immunoglobulin g|glycosylation modification

Published in Jichu yixue yu linchuang

ISSN: 1001-6325 (Print)
Publisher: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Country of publisher: China
LCC subjects: Medicine
Website: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/1001-6325/home.shtml

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