Programmed cell death and processes of lipid peroxidation in metabolic syndrome

Abstract

The purpose: To study possible interconnection between programmed cell death and the processes of lipid peroxidation in the patients with metabolic syndrome. Material and Methods: 270 patients with metabolic syndrome at the age of 30 till 60 (162 men and 108 women) have been examined. MC diagnostic was based on the criteria recommended by experts of society of cardiologists of Russia (2009). Lipid peroxidation was estimated according to the content of hydroperoxide (mkM), the programmed cell death process was studied with protein p53 concentration determination; high sensitivity C-reactive protein content in blood serum was studied by enzyme multiplied immunoassay method (ELISA). Results: In the patients with metabolic syndrome the programmed cell death processes and lipid peroxidation are intensified. High level of lipid hydroperoxide indicates it — 2,89(1,94; 4,1) mkM and protein p53-1,59 (1,361,91) U/ ml in blood serum. Strict direct correlation between lipid peroxidation level and body weight index was defined (r+0,77, p<0,05). Conclusion: Researched processes are interconnected. Strict positive correlation between hydroperoxide level and protein p53 (r+0,71, p<0,05) concentration was defined, their intensity grows parallel to body weight index.55,2% of patients with metabolic syndrome have high risk of development of cardiovascular complications because high sensitivity C-reactive protein content is more than 3mg/l.

Keywords

• lipid peroxidation
• metabolic syndrome
• programmed cell death