Проблемы особо опасных инфекций (Jun 2008)

F(ab’)<sub>2</sub>-Fragments of Antirabic Immunoglobulin Production Using Immobilized Pepsin

  • S. V. Generalov,
  • E. G. Abramova,
  • A. K. Nikiforov,
  • E. M. Hramkova,
  • I. A. Shepelev,
  • L. V. Savitskaya,
  • L. N. Minaeva,
  • M. V. Galkina,
  • T. A. Miheeva,
  • N. N. Kochkalova,
  • M. N. Kireev

DOI
https://doi.org/10.21055/0370-1069-2008-3(97)-53-56
Journal volume & issue
Vol. 0, no. 3(97)
pp. 53 – 56

Abstract

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Biotechnological scheme for F(ab')2-fragments of anti-rabies immunoglobulin production using immobilized pepsin was developed. Optimal ways for immobilized pepsin production were determined, conditions for fermentative hydrolysis of anti-rabies immunoglobulin were sorted out. Protective properties of F(ab')2-fragments of anti-rabies immunoglobulin produced by means of this method were assessed.

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