Nature Communications (Apr 2017)

Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice

  • Zhenyu Zhong,
  • Yougang Zhai,
  • Ping Bu,
  • Shivanee Shah,
  • Liang Qiao

DOI
https://doi.org/10.1038/ncomms15004
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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Innate immunity sensors are expressed by both tumour cells and tumour-associated myeloid cells. Here, the authors show that stimulation of the innate immunity response with pseudoviruses in a genetic mouse model of intestinal cancer triggers tumour regression via Caspase-1 activation.