Nature Communications (Apr 2017)
Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice
Abstract
Innate immunity sensors are expressed by both tumour cells and tumour-associated myeloid cells. Here, the authors show that stimulation of the innate immunity response with pseudoviruses in a genetic mouse model of intestinal cancer triggers tumour regression via Caspase-1 activation.