International Journal of Nanomedicine (Apr 2022)

Targeted Therapy for Inflammatory Diseases with Mesenchymal Stem Cells and Their Derived Exosomes: From Basic to Clinics

  • Wang S,
  • Lei B,
  • Zhang E,
  • Gong P,
  • Gu J,
  • He L,
  • Han L,
  • Yuan Z

Journal volume & issue
Vol. Volume 17
pp. 1757 – 1781

Abstract

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Shuo Wang,1 Biyu Lei,1 E Zhang,2 Puyang Gong,1 Jian Gu,1 Lili He,1 Lu Han,1 Zhixiang Yuan1 1College of Pharmacy, Southwest Minzu University, Chengdu, 610041, Sichuan, People’s Republic of China; 2Department of Basic Sciences, Officers College of People’s Armed Police, Chengdu, Sichuan, 610213, People’s Republic of ChinaCorrespondence: Zhixiang Yuan; Lu Han, Email [email protected]; [email protected]: Inflammation is a beneficial and physiological process, but there are a number of inflammatory diseases which have detrimental effects on the body. In addition, the drugs used to treat inflammation have toxic side effects when used over a long period of time. Mesenchymal stem cells (MSCs) are pluripotent stem cells that can be isolated from a variety of tissues and can be differentiate into diverse cell types under appropriate conditions. They also exhibit noteworthy anti-inflammatory properties, providing new options for the treatment of inflammatory diseases. The therapeutic potential of MSCs is currently being investigated for various inflammatory diseases, such as kidney injury, lung injury, osteoarthritis (OA), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD). MSCs can perform multiple functions, including immunomodulation, homing, and differentiation, to enable damaged tissues to form a balanced inflammatory and regenerative microenvironment under severe inflammatory conditions. In addition, accumulated evidence indicates that exosomes from extracellular vesicles of MSCs (MSC-Exos) play an extraordinary role, mainly by transferring their components to recipient cells. In this review, we summarize the mechanism and clinical trials of MSCs and MSC-Exos in various inflammatory diseases in detail, with a view to contributing to the treatment of MSCs and MSC-Exos in inflammatory diseases.Keywords: mesenchymal stem cells, exosome, inflammatory diseases, clinic data, drug delivery, targeted therapy

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