Nature Communications (Nov 2020)
The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition
Abstract
Human Long INterspersed Element class 1 (LINE-1) elements are expressed and mobilized in many types of cancer, contributing to malignancy. Here the authors show that the tumor suppressor microRNA let-7 targets the LINE-1 mRNA and reduces LINE-1 mobilization.