Nature Communications (Nov 2020)

The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition

  • Pablo Tristán-Ramos,
  • Alejandro Rubio-Roldan,
  • Guillermo Peris,
  • Laura Sánchez,
  • Suyapa Amador-Cubero,
  • Sebastien Viollet,
  • Gael Cristofari,
  • Sara R. Heras

DOI
https://doi.org/10.1038/s41467-020-19430-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Human Long INterspersed Element class 1 (LINE-1) elements are expressed and mobilized in many types of cancer, contributing to malignancy. Here the authors show that the tumor suppressor microRNA let-7 targets the LINE-1 mRNA and reduces LINE-1 mobilization.