Nature Communications (Jul 2022)

Modulating mitofusins to control mitochondrial function and signaling

  • Emmanouil Zacharioudakis,
  • Bogos Agianian,
  • Vasantha Kumar MV,
  • Nikolaos Biris,
  • Thomas P. Garner,
  • Inna Rabinovich-Nikitin,
  • Amanda T. Ouchida,
  • Victoria Margulets,
  • Lars Ulrik Nordstrøm,
  • Joel S. Riley,
  • Igor Dolgalev,
  • Yun Chen,
  • Andre J. H. Wittig,
  • Ryan Pekson,
  • Chris Mathew,
  • Peter Wei,
  • Aristotelis Tsirigos,
  • Stephen W. G. Tait,
  • Lorrie A. Kirshenbaum,
  • Richard N. Kitsis,
  • Evripidis Gavathiotis

DOI
https://doi.org/10.1038/s41467-022-31324-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 20

Abstract

Read online

Mitofusins regulate mitochondrial fusion. Here the authors identify small molecules that activate or inhibit mitofusins’ activity and modulate mitochondrial fusion and functionality. Inhibition of mitochondrial fusion promotes minority MOMP, caspase-3/7 activation, and DNA damage.