Nature Communications (Sep 2021)

A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression

  • Jing Liu,
  • Daniela Ottaviani,
  • Meriem Sefta,
  • Céline Desbrousses,
  • Elodie Chapeaublanc,
  • Rosario Aschero,
  • Nanor Sirab,
  • Fabiana Lubieniecki,
  • Gabriela Lamas,
  • Laurie Tonon,
  • Catherine Dehainault,
  • Clément Hua,
  • Paul Fréneaux,
  • Sacha Reichman,
  • Narjesse Karboul,
  • Anne Biton,
  • Liliana Mirabal-Ortega,
  • Magalie Larcher,
  • Céline Brulard,
  • Sandrine Arrufat,
  • André Nicolas,
  • Nabila Elarouci,
  • Tatiana Popova,
  • Fariba Némati,
  • Didier Decaudin,
  • David Gentien,
  • Sylvain Baulande,
  • Odette Mariani,
  • Florent Dufour,
  • Sylvain Guibert,
  • Céline Vallot,
  • Livia Lumbroso-Le Rouic,
  • Alexandre Matet,
  • Laurence Desjardins,
  • Guillem Pascual-Pasto,
  • Mariona Suñol,
  • Jaume Catala-Mora,
  • Genoveva Correa Llano,
  • Jérôme Couturier,
  • Emmanuel Barillot,
  • Paula Schaiquevich,
  • Marion Gauthier-Villars,
  • Dominique Stoppa-Lyonnet,
  • Lisa Golmard,
  • Claude Houdayer,
  • Hervé Brisse,
  • Isabelle Bernard-Pierrot,
  • Eric Letouzé,
  • Alain Viari,
  • Simon Saule,
  • Xavier Sastre-Garau,
  • François Doz,
  • Angel M. Carcaboso,
  • Nathalie Cassoux,
  • Celio Pouponnot,
  • Olivier Goureau,
  • Guillermo Chantada,
  • Aurélien de Reyniès,
  • Isabelle Aerts,
  • François Radvanyi

DOI
https://doi.org/10.1038/s41467-021-25792-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 20

Abstract

Read online

Retinoblastoma is the most frequent intraocular paediatric malignancy whose molecular basis remains poorly understood. Here, the authors perform multi-omic analysis and identify two subtypes; one in a cone differentiated state and one more aggressive showing cone dedifferentiation and expressing neuronal markers.