Clinical significance of prognostic nutritional index in myelodysplastic syndrome

Yue Chen; Junhui Wang; Jingjing Ma; Linrong Fei; Qiuni Chen; Shandong Tao; Zhengmei He; Chunling Wang; Liang Yu

doi:10.1080/16078454.2022.2161209

Hematology (Dec 2023)

Clinical significance of prognostic nutritional index in myelodysplastic syndrome

Yue Chen,
Junhui Wang,
Jingjing Ma,
Linrong Fei,
Qiuni Chen,
Shandong Tao,
Zhengmei He,
Chunling Wang,
Liang Yu

Affiliations

Yue Chen: Department of Hematology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian, People’s Republic of China
Junhui Wang: Department of Hematology, the Huai’an Clinical College of Xuzhou Medical University, Huai’an, People’s Republic of China
Jingjing Ma: Department of Hematology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian, People’s Republic of China
Linrong Fei: Department of Hematology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian, People’s Republic of China
Qiuni Chen: Department of Hematology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian, People’s Republic of China
Shandong Tao: Department of Hematology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian, People’s Republic of China
Zhengmei He: Department of Hematology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian, People’s Republic of China
Chunling Wang: Department of Hematology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian, People’s Republic of China
Liang Yu: Department of Hematology, the Huai’an Clinical College of Xuzhou Medical University, Huai’an, People’s Republic of China

DOI: https://doi.org/10.1080/16078454.2022.2161209
Journal volume & issue: Vol. 28, no. 1

Abstract

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ABSTRACTBackground Prognostic nutritional index has been found to be related to the clinical outcomes of patients with cancer. However, its role in myelodysplastic syndromes (MDS) patients is unclear. We aimed to assess the value of nutritional status in predicting the prognosis of MDS patients.Methods Totally 121 MDS patients were analyzed retrospectively. The prognostic nutritional index (PNI) was used to assess nutritional status of the patients. The bio-informatics tool X-tile was used to define the threshold, and accordingly patients were divided into PNIlow and PNIhigh groups, the characteristics were compared between two groups.Results The PNIhigh was associated with better OS (Overall Survival) than PNIlow in MDS patients (Median OS, 28.03 months versus 19.63 months, P = 0.0205). But there were no statistical differences in PFS (Progression-Free-Survival) between the two groups (P = 0.9373). The univariable and multivariable COX proportional hazard analysis adjusted for age, gender, platelet count, HB level and IPSS-R scores, and the results showed that PNI is a useful index in the evaluation of the OS of MDS (HR 0.588, 95%CI 0.374–0.926, P = 0.024).Conclusion PNI would be a simple and immediately available tool for predicting the prognosis of MDS.

Published in Hematology

ISSN: 1024-5332 (Print); 1607-8454 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: https://www.tandfonline.com/journals/yhem

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