Study on the Relationship between Pro-Brain Natriuretic Peptide and Routine Blood Test Factors at a General Hospital in Gyeonggi-do

Abstract

This study investigated retrospectively the correlation between the results of the N-terminal pro-brain natriuretic peptide (NT-proBNP) and a routine blood test using a hospital information system. The NT-proBNP is involved in the pathophysiology of heart failure. The results show that the relationship between age and NT-proBNP was significant (P＜0.01) with a positive correlation (r=0.163). The peptide concentration showed a negative correlation between the total protein (r=−0.250) and albumin (r=−0.270), and a negative correlation between the erythrocyte count and hemoglobin and hematocrit (P＜0.01). NT-proBNP had a positive correlation with neutrophils (r=0.227) and a negative correlation with lymphocytes (r=-0.236), showing significant results (P＜0.01). NT-proBNP and creatinine showed a positive correlation (r=0.594, P＜0.01), and it was the most influential factor according to multiple regression analysis (B=0.53, t=7.65). P＜0.01). The concentra-tions of NT-proBNP and uric acid showed a positive correlation (r=0.180, P＜0.05). Lactate dehyd-rogenase was observed as a factor affecting the NT-proBNP (B=0.20, t=3.28, P＜0.01). This explanatory power had an influence of 43%. Therefore, the accurate test and related factors of the NT-proBNP have significant clinical value.

Keywords

• cardiac marker
• creatinine
• lactate dehydrogenase
• pro-brain natriuretic peptide