Nature Communications (Dec 2019)
Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease
- Jörn F. Ziegler,
- Chotima Böttcher,
- Marilena Letizia,
- Cansu Yerinde,
- Hao Wu,
- Inka Freise,
- Yasmina Rodriguez-Sillke,
- Ani K. Stoyanova,
- Martin E. Kreis,
- Patrick Asbach,
- Desiree Kunkel,
- Josef Priller,
- Ioannis Anagnostopoulos,
- Anja A. Kühl,
- Konstanze Miehle,
- Michael Stumvoll,
- Florian Tran,
- Broder Fredrich,
- Michael Forster,
- Andre Franke,
- Christian Bojarski,
- Rainer Glauben,
- Britt-Sabina Löscher,
- Britta Siegmund,
- Carl Weidinger
Affiliations
- Jörn F. Ziegler
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Chotima Böttcher
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Marilena Letizia
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Cansu Yerinde
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Hao Wu
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Inka Freise
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Yasmina Rodriguez-Sillke
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Ani K. Stoyanova
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Martin E. Kreis
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Patrick Asbach
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Desiree Kunkel
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Josef Priller
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Ioannis Anagnostopoulos
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Anja A. Kühl
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Konstanze Miehle
- Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center
- Michael Stumvoll
- Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center
- Florian Tran
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Broder Fredrich
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Michael Forster
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Andre Franke
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Christian Bojarski
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Rainer Glauben
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Britt-Sabina Löscher
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Britta Siegmund
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Carl Weidinger
- Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- DOI
- https://doi.org/10.1038/s41467-019-13559-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
The adipokine leptin modulates intestinal inflammation in mice. Here the authors describe a patient with inflammatory bowel disease and lipodystrophy, providing evidence that leptin aggravates intestinal inflammation with proinflammatory effects on leukocytes that are reversible by TNFα blockade.
