Nature Communications (Feb 2017)

Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions

  • Edik M. Blais,
  • Kristopher D. Rawls,
  • Bonnie V. Dougherty,
  • Zhuo I. Li,
  • Glynis L. Kolling,
  • Ping Ye,
  • Anders Wallqvist,
  • Jason A. Papin

DOI
https://doi.org/10.1038/ncomms14250
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

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The rat is a widely-used model for human biology, but we must be aware of metabolic differences. Here, the authors reconstruct the genome-scale metabolic network of the rat, and after reconciling it with an improved human metabolic model, demonstrate the power of the models to integrate toxicogenomics data, providing species-specific biomarker predictions in response to a panel of drugs.