Topoisomerase 2β Induces DNA Breaks To Regulate Human Papillomavirus Replication

Paul Kaminski; Shiyuan Hong; Takeyuki Kono; Paul Hoover; Laimonis Laimins

doi:10.1128/mBio.00005-21

mBio (Feb 2021)

Topoisomerase 2β Induces DNA Breaks To Regulate Human Papillomavirus Replication

Paul Kaminski,
Shiyuan Hong,
Takeyuki Kono,
Paul Hoover,
Laimonis Laimins

Affiliations

Paul Kaminski: Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
Shiyuan Hong: Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
Takeyuki Kono: Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
Paul Hoover: Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
Laimonis Laimins: ORCiD; Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

DOI: https://doi.org/10.1128/mBio.00005-21
Journal volume & issue: Vol. 12, no. 1

Abstract

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High-risk human papillomaviruses (HPVs) infect epithelial cells and induce viral genome amplification upon differentiation. HPV proteins activate DNA damage repair pathways by inducing high numbers of DNA breaks in both viral and cellular DNAs.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal