mBio
(Feb 2021)
Topoisomerase 2β Induces DNA Breaks To Regulate Human Papillomavirus Replication
Paul Kaminski,
Shiyuan Hong,
Takeyuki Kono,
Paul Hoover,
Laimonis Laimins
Affiliations
Paul Kaminski
Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
Shiyuan Hong
Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
Takeyuki Kono
Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
Paul Hoover
Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
Laimonis Laimins
ORCiD Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
DOI
https://doi.org/10.1128/mBio.00005-21
Journal volume & issue
Vol. 12,
no. 1
Abstract
Read online
High-risk human papillomaviruses (HPVs) infect epithelial cells and induce viral genome amplification upon differentiation. HPV proteins activate DNA damage repair pathways by inducing high numbers of DNA breaks in both viral and cellular DNAs.
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